BACKGROUND: Femoroacetabular impingement syndrome (FAIS) is a motion-related and position-related clinical condition of the hip associated with pain, reduced physical function and hip-related quality of life (QoL). Interestingly, higher maximal muscle strength is associated with less pain, better physical function and improved QoL in people with FAIS. Furthermore, preliminary evidence suggests that a proportion of patients with FAIS respond positively to strength exercise as first-line treatment. Nonetheless, there is little evidence supporting a specific exercise intervention offered as a first-line treatment. We will conduct a randomised controlled trial investigating the clinical effectiveness and cost-effectiveness of a 6-month strength exercise intervention compared with usual care as first-line treatment in patients with FAIS.
METHODS: This is a multicentre randomised controlled trial that will be conducted at hospitals and physiotherapy clinics across Denmark and Australia. A total of 120 patients with FAIS will be randomised (1:1) to 6 months of supervised strength exercise or usual care. The primary outcome is the change in hip-related QoL measured using the International Hip and Outcome Tool 33 (iHOT-33) from baseline to the end of intervention. A health economic evaluation will be conducted from a societal and healthcare perspective based on the data collection over a 12-month period starting at baseline. The analysis will calculate incremental cost-effectiveness ratios using quality-adjusted life-years and iHOT-33 scores while estimating costs using microcosting and cost questionnaires. Secondary outcomes include objectively measured physical function at baseline and after 6 months and patient-reported outcomes measured at baseline, 3-month, 6-month and 12-month follow-up.
BACKGROUND: The trial has been approved by the Committee on Health Research Ethics in the Central Denmark Region (journal no 1-10-72-45-23) and La Trobe University Human Ethics Committee (HEC24042) and is registered at the Central Denmark Region List of Research Projects (journal no 1-16-02-115-23). Informed consent will be obtained from each participant before randomisation. Results will be published in international peer-reviewed scientific journals.
BACKGROUND: NCT05927935.

OBJECTIVE: Post-stroke cognitive impairment (PSCI) is highly prevalent in modern society. However, there is limited study implying an accurate and explainable machine learning model to predict PSCI. The aim of this study is to develop and validate a web-based artificial intelligence (AI) tool for predicting PSCI.
METHODS: The retrospective cohort study design was conducted to develop and validate a web-based prediction model. Adults who experienced a stroke between January 1, 2004, and September 30, 2017, were enrolled, and patients with PSCI were followed up from the stroke index date until their last follow-up. The model\'s performance metrics, including accuracy, area under the curve (AUC), recall, precision, and F1 score, were compared.
RESULTS: A total of 3,209 stroke patients were included in the study. The model demonstrated an accuracy of 0.8793, AUC of 0.9200, recall of 0.6332, precision of 0.9664, and F1 score of 0.7651. In the external validation phase, the accuracy improved to 0.9039, AUC to 0.9094, recall to 0.7457, precision to 0.9168, and F1 score to 0.8224. The final model can be accessed at https://psci-calculator.my.id/.
CONCLUSIONS: Our results are able to produce a user-friendly interface that is useful for health practitioners to perform early prediction on PSCI. These findings also suggest that the provided AI model is reliable and can serve as a roadmap for future studies using AI models in a clinical setting.

BACKGROUND: Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth disorders, neuromuscular problems, impaired motor coordination, and decreased muscle tone. However, it is not known whether loss of muscle strength occurs, and which interventions will effectively mitigate physical PAE impairments. We aimed to investigate whether physical alteration persists during adolescence and whether exercise is an effective intervention.
RESULTS: Using paradigms to evaluate different physical qualities, we described that early adolescent PAE animals have significant alterations in agility and strength, without alterations in balance and coordination compared to CTRL animals. We evaluated the effectiveness of 3 different exercise protocols for 4 weeks: Enrichment environment (EE), Endurance exercise (EEX), and Resistance exercise (REX). The enriched environment significantly improved the strength in the PAE group but not in the CTRL group whose strength parameters were maintained even during exercise. Resistance exercise showed the greatest benefits in gaining strength, and endurance exercise did not.
CONCLUSIONS: PAE induced a significant decrease in strength compared to CTRL in PND21. Resistance exercise is the most effective to reverse the effects of PAE on muscular strength. Our data suggests that individualized, scheduled, and supervised training of resistance is more beneficial than endurance or enriched environment exercise for adolescents FASD.

UNASSIGNED: To explore whether blood flow-restrictive resistance exercise (BFRE) can be used as an alternative strategy to moderate-intensity resistance training (RT) to improve metabolic disorder and body composition in older adults with type 2 diabetes (T2DM).
UNASSIGNED: This is a single-blind, randomized, controlled trial. Ninety-eight older adults with T2DM were randomly divided into three groups: BFRE group (n = 34), RT group (n = 31) and control group (n = 33). Two exercise groups received supervised collective training for a period of six months, each lasting 50 min, three times a week. The primary outcomes included fasting plasma glucose (FPG), Glycosylated hemoglobin (HbA1c), blood lipids, blood pressure, and body composition. The secondary outcome was muscle performance.
UNASSIGNED: After six months of intervention, the FPG, HbA1c, blood lipids, diastolic blood pressure, body composition, and muscle performance of the two exercise groups were significantly improved relative to the control group and baseline measurements (P < 0.05). There was no significant increase in lean mass between the two exercise groups compared to the control group and baseline (p > 0.05). There was no significant decrease in systolic blood pressure between the two exercise groups compared to the control group (p > 0.05), but it was significantly lower than their baseline (P < 0.05). There was no significant difference in all indicators between the two exercise groups at the baseline, third and sixth months of intervention (p > 0.05).
UNASSIGNED: BFRE can safely and effectively improve the metabolic disorder and body composition of older adults with T2DM. For elderly exercise beginners, BFRE can be used as an alternative strategy to moderate-intensity resistance training.
UNASSIGNED: https://www.chictr.org.cn/showproj.html?proj=178886, identifier ChiCTR2300074357.

UNASSIGNED: Hypertension is a primary risk factor for cardiovascular disease and all-cause mortality. This study investigated sex-based differences in the association between the risk of hypertension and resistance training (RT) levels, including training frequency and period.
UNASSIGNED: We enrolled 162,102 participants from nationwide Korean cohorts. The training period (months) and frequency (per week) of RT were used to investigate the presence of an inverse dose-response relationship between RT levels and the risk of hypertension. Multiple logistic regression models were used to evaluate the risk of hypertension in relation to RT levels.
UNASSIGNED: The prevalence of hypertension in the study population was 36.28% in men and 26.94% in women. Performing RT was associated with an 8% reduction in the risk of hypertension in women but not in men. In women, performing RT for 3-4 days/week, compared with not performing RT, reduced the risk of hypertension by 11%, even after adjusting for covariates, including RT time per week and period. However, in men, no significant association was observed between training frequency and the risk of hypertension. We also evaluated the risk of hypertension by simultaneously considering both the RT frequency and period. Performing RT for 3-4 days/week and ≥5 days/week were markedly related to 14 and 11% hypertension risk reduction, respectively, in women who had been performing RT for at least 6 months.
UNASSIGNED: Given that no inverse dose-response association was observed between RT frequency and hypertension risk, engaging in RT for 3-4 days/week for at least 6 months is recommended for women. Further longitudinal studies are needed to verify sex-based differences in the antihypertensive effects of regular RT.

UNASSIGNED: Kotikangas, J, Walker, S, Peltonen, H, and Häkkinen, K. Time course of neuromuscular fatigue during different resistance exercise loadings in power athletes, strength athletes, and nonathletes. J Strength Cond Res 38(7): 1231-1242, 2024-Training background may affect the progression of fatigue and neuromuscular strategies to compensate for fatigue during resistance exercises. Thus, our aim was to examine how training background affects the time course of neuromuscular fatigue in response to different resistance exercises. Power athletes (PA, n = 8), strength athletes (SA, n = 8), and nonathletes (NA, n = 7) performed hypertrophic loading (HL, 5 × 10 × 10RM), maximal strength loadings (MSL, 7 × 3 × 3RM) and power loadings (PL, 7 × 6 × 50% of 1 repetition maximum) in back squat. Average power (AP), average velocity (VEL), surface electromyography (sEMG) amplitude (sEMGRMS), and sEMG mean power frequency (sEMGMPF) were measured within all loading sets. During PL, greater decreases in AP occurred from the beginning of SET1 to SET7 and in VEL to both SET4 and SET7 in NA compared with SA (p < 0.01, g > 1.84). During HL, there were various significant group × repetition interactions in AP within and between sets (p < 0.05, ηp2 > 0.307), but post hoc tests did not indicate significant differences between the groups (p > 0.05, g = 0.01-0.93). During MSL and HL, significant within-set and between-set decreases occurred in AP (p < 0.001, ηp2 > 0.701) and VEL (p < 0.001, ηp2 > 0.748) concurrently with increases in sEMGRMS (p < 0.01, ηp2 > 0.323) and decreases in sEMGMPF (p < 0.01, ηp2 > 0.242) in all groups. In conclusion, SA showed fatigue resistance by maintaining higher AP and VEL throughout PL. During HL, PA tended to have the greatest initial fatigue response in AP, but between-group comparisons were nonsignificant despite large effect sizes (g > 0.8). The differences in the progression of neuromuscular fatigue may be related to differing neural activation strategies between the groups, but further research confirmation is required.

UNASSIGNED: de Lemos Muller, CH, Farinha, JB, Leal-Menezes, R, and Ramis, TR. Aerobic training with blood flow restriction on muscle hypertrophy and strength: systematic review and meta-analysis. J Strength Cond Res 38(7): 1341-1349, 2024-Integrating strength and endurance training in a single exercise session, even on separate days, can be physically demanding and time-consuming. Therefore, there is a growing interest in identifying efficient training methods that can concurrently enhance cardiovascular and neuromuscular performance through a singular training modality. This study conducted a systematic review and meta-analysis to explore the effects of aerobic training with blood flow restriction (AT + BFR) on muscle hypertrophy and strength gains in healthy individuals. Our study was registered at PROSPERO and used multiple databases (PubMed, Embase, Scopus, and Web of Science), seeking clinical trials that examined AT + BFR influence on muscle hypertrophy and strength gains in individuals aged 18-60 years and comparing with aerobic training without BFR. The risk of bias and method quality were assessed using the ROB2.0 tool and PEDro scale, respectively, and the quality of evidence was evaluated with the GRADE method. A random-effects model was used for meta-analysis, and standardized mean difference (SMD) was calculated for each outcome. Of 4,462 records, 29 full texts were assessed for eligibility, with 7 articles meeting the inclusion criteria. The results indicated that AT + BFR was more beneficial for inducing muscle hypertrophy than aerobic training without BFR (SMD [95% CI] = 0.86 [0.37-1.35]; I2 = 42%). Furthermore, AT + BFR was associated with greater improvements in muscle strength (SMD [95% CI] = 0.41 [0.10-0.72]; I2 = 0%). Despite the generally high risk of bias for both outcomes, these encouraging findings underscore the clinical significance of AT + BFR as a compelling tool for enhancing neuromuscular parameters.

UNASSIGNED: Suchomel, TJ, Techmanski, BS, Kissick, CR, and Comfort, P. Can the velocity of a 1RM hang power clean be used to estimate a 1RM hang high pull? J Strength Cond Res 38(7): 1321-1325, 2024-The purpose of this study was to estimate the 1-repetition maximum hang high pull (1RM HHP) using the peak barbell velocity of a 1RM hang power clean (HPC). Fifteen resistance-trained men (age = 25.5 ± 4.5 years, body mass = 88.3 ± 15.4 kg, height = 176.1 ± 8.5 cm, relative 1RM HPC = 1.3 ± 0.2 kg·kg-1) with previous HPC experience participated in 2 testing sessions that included performing a 1RM HPC and HHP repetitions with 20, 40, 60, and 80% of their 1RM HPC. Peak barbell velocity was measured using a linear position transducer during the 1RM HPC and HHP repetitions performed at each load. The peak barbell velocity achieved during the 1RM HPC was determined as the criterion value for a 1RM performance. Subject-specific linear regression analyses were completed using slope-intercept equations created from the peak velocity of the 1RM HPC and the peak barbell velocities produced at each load during the HHP repetitions. The peak barbell velocity during the 1RM HPC was 1.74 ± 0.30 m·s-1. The average load-velocity profile showed that the estimated 1RM HHP of the subjects was 98.0 ± 19.3% of the 1RM HPC. Although a 1RM HHP value may be estimated using the peak barbell velocity during the HPC, strength and conditioning practitioners should avoid this method because of the considerable variation within the measurement. Additional research examining different methods of load prescription for weightlifting pulling derivatives is needed.

UNASSIGNED: Moreno, MR, Dawes, JJ, Orr, RM, Dulla, JM, and Lockie, RG. Relationships between strength and power with the 74.84-kg (165-lb) and 90.72-kg (200-lb) body drags. J Strength Cond Res 38(7): 1305-1313, 2024-A body drag is an essential job task in law enforcement. It is purported that strength and power should contribute to this task, but there has been limited analysis. This study examined strength (1-repetition maximum hexagonal bar deadlift [1RM HBD]) and power (vertical jump [VJ], standing broad jump [SBJ]) relationships with the 74.84-kg and 90.72-kg body drags. Forty-three civilians (24 men and 19 women) completed the SBJ, VJ, and 1RM HBD in 1 session. Peak anaerobic power measured in watts (PAPw) was derived from the VJ. Relative measures were calculated from the SBJ, PAPw, and HBD. In another 2 sessions, subjects completed 74.84-kg and 90.72-kg drags in a counterbalanced order using 2 techniques: standard and adapted (time taken to pick dummy up from ground included in time). Independent samples t-tests compared the sexes and subjects who could or could not complete all drags. Partial correlations and stepwise regression, both controlling for sex, examined relationships between strength and power and the drags. In general, men outperformed women in almost all tests (p ≤ 0.024). Thirty-five subjects completed all drags and were stronger and more powerful than subjects who could not (p ≤ 0.011). The SBJ correlated with the 74.84-kg standard (r = -0.355) and 90.72-kg adapted (r = -0.373) drags; the VJ correlated with the 74.84-kg standard drag (r = -0.356). Peak anaerobic power measured in watts and 1RM HBD correlated with all drags (r = -0.382 to -0.668); PAPw was involved in all significant predictive relationships (explained variance = 34-62%). Absolute strength and power training should be a focus for recruits to enhance their ability to perform dragging tasks, especially with heavier masses.

UNASSIGNED: Hill, V, Patterson, S, Buckthorpe, M, and Legg, HS. The acute effects of a preload upper-body power exercise on 50-m freestyle performance in youth swimmers. J Strength Cond Res 38(7): 1295-1299, 2024-This study aimed to investigate the acute effects of a medicine ball slam and the optimal recovery time required to induce a postactivation performance enhancement (PAPE) response on 50-meter freestyle swimming performance. Twenty-four (13 female, 11 male) competitive, adolescent swimmers (mean ± SD: age, 16.7 ± 1.2 years; height, 173.3 ± 6.7 cm; mass, 63.1 ± 6.4 kg) participated in a randomized crossover study. After the PAPE intervention (3 × 5 medicine ball slams), subjects had 1-minute, 4-minute, and 8-minute recovery periods before a 50-m maximal freestyle swim. A 1-way repeated-measures ANOVA revealed that different recovery times elicited changes in 50-m performance (F = 12.12, p < 0.0005). After 4 minutes of recovery, 50-m performance was 1.6% (0.47 seconds) faster (95% confidence interval [CI] [0.17-0.77], p < 0.001). When the data were split by sex, after 4 minutes of recovery, 50-m performance was 2% (0.64 seconds) faster for women (95% CI [0.279-0.998], p < 0.001). In conclusion, an upper-body power exercise, before performance, can induce a PAPE response and enhance 50-m freestyle performance after a 4-minute recovery period.